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KMID : 0369820120420050271
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Jorunal of Korean Pharmaceutical Sciences
2012 Volume.42 No. 5 p.271 ~ p.277
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Diffusion properties of different compounds across various synthetic membranes using Franz-type diffusion cells
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Jung Youn-Jung
Yoon Jeong-Hyun
Kang Nae-Gyu
Park Sun-Gyoo
Jeong Seong-Hoon
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Abstract
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Diffusion properties of typical functional cosmetic ingredients, niacinamide, ascorbic acid 2-glucoside, retinol and polyethoxylated retinamide, were evaluated across various synthetic membranes using Franz-type diffusion cells. Different kinds of artificial membranes available in the market were utilized for comparing how the functional ingredients diffuse through the membrane. Niacinamide and ascorbic acid 2-glucoside were resulted out similar diffusion pattern. On the other hands, retinol and polyethoxylated retinamide showed similar diffusion pattern. This might be due to their hydrophilic properties. Moreover, physicochemical properties of the membranes, pore size, and/or membrane thickness need to be considered as well. Solvents and composition of the donor and receptor compartment are the factors to investigate in detail to obtain systematic information regarding the diffusion properties. The results might help when to evaluate and analyze topical formulations in a faster and reproducible way.
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KEYWORD
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Diffusion, Franz cell, Synthetic membrane, Niacinamide, Ascorbic acid 2-glucoside, Retinol, Polyethoxylated retinamide
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